Date: 8 months ago   Category: Medicine

Have deceived cancer. For what have given Nobel on medicine


The Nobel Prize was handed for researches in the field of a new type of cancer therapy - an immunotherapy which works "due to suppression of negative immune regulation". Nobel Prize laureates on physiology and medicine in 2018 became James Allison and to Tasuk Hondze for "absolutely new principle" of therapy of oncological diseases. Scientists managed "to deceive" cancer cells and not to allow them to suppress immune reaction of an organism. It has made the real revolution in therapy and has formed the basis of the whole new class of medicines. Корреспондент.net tells details. Epoch-making opening the Nobel Prize on medicine in 2018 was got by the 70-year-old American James Allison and the 76-year-old Japanese Tasuka Hondze. Their opening in the field of immunology have helped to create new effective ways of cancer therapy. Each of scientists will receive 500 thousand dollars. Allison and Hondze have established "absolutely new principle of cancer therapy", it is told in the press release of the Nobel committee. "Epoch-making opening of these two winners became a turning point in our fight against cancer", - it is noted in the message. Scientists have developed essentially new approach to therapy of cancer, excellent from existing before radiotheraphy and chemotherapy which is known as "inhibition of chekpoynt (immune control points - an edition)" immunity cages. Write in English-speaking literature on this therapy that she "removes immunity from a brake". Immune control points are a natural mechanism which brakes immunity, "calming" the T-lymphocytes responsible for recognition and destruction of the alien and mutating cages. If this mechanism is broken, then the organism begins to destroy itself, having switched to destruction of healthy fabrics. So, for example, occurs at autoimmune diseases. One of the main problems of oncology is that the human immune system most often doesn't "see" malignant tumors as cancer cells, on the one hand, differ from our own, on the other hand, are them. Doesn't result from necessary protective reaction of an organism to cancer cells. Researches of Nobel laureates are devoted to how to eliminate suppression of activity of cages of immune system from cancer cells. The Japanese immunologist from the university of Kyoto has opened PD-1 receptor (a control point of immunity) on a surface of lymphocytes which activation leads to suppression of their activity. His American colleague from the Andersonovsky cancer center of the university of Texas has tried to switch-off the natural brake mechanism at suffering from cancer mice - and has achieved surprising results. Tumor cells couldn't disappear from immunity any more, and the organism struggled with cancer much more effectively. New medicine against cancer of the Research of these two immunologists was led to emergence of a new class of anticarcinogenic medicines on the basis of the antibodies contacting proteins on a surface of lymphocytes, or cancer cells. The first such medicine, ипилимумаб - the antibody blocking CTLA-4 (a control point of an immuna

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